منابع مشابه
RhoA Regulation of Cardiomyocyte Differentiation
Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promo...
متن کاملMolecular regulation of cardiomyocyte differentiation.
The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in ≈1 percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest...
متن کاملInhibition of cardiomyocyte differentiation by cADPR
Background: The role and mechanism of cADPR, an endogenous Ca 2+ mobilizing nucleotide, in cardiomyogenesis remain to be determined. Results: We found that inhibition of the cADPR cascade facilitated cardiomyocyte differentiation of mouse ES cells. Conclusion: The CD38-cADPR-Ca 2+ signaling pathway antagonizes the cardiomyocyte differentiation of mouse ES cells. Significance: Inhibition of cADP...
متن کاملLoss of β2-spectrin prevents cardiomyocyte differentiation and heart development.
AIMS β2-Spectrin is an actin-binding protein that plays an important role in membrane integrity and the transforming growth factor (TGF)-β signalling pathway as an adaptor for Smads. Loss of β2-spectrin in mice (Spnb2(-/-)) results in embryonic lethality with gastrointestinal, liver, neural, and heart abnormalities that are similar to those in Smad2(+/-)Smad3(+/-) mice. However, to date, the ro...
متن کاملComparison of random and aligned PCL nanofibrous electrospun scaffolds on cardiomyocyte differentiation of human adipose-derived stem cells
Objective(s):Cardiomyocytes have small potentials for renovation and proliferation in adult life. The most challenging goal in the field of cardiovascular tissue engineering is the creation of an engineered heart muscle. Tissue engineering with a combination of stem cells and nanofibrous scaffolds has attracted interest with regard to Cardiomyocyte creation applications. Human adipose-derived s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2000
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.115.337